¶ Interactions Database

¶ What This Is (and Isn’t)

• This is: a structured way to identify interaction risk and decide when to avoid self-experimentation.
• This isn’t: a substitute for a clinician, pharmacist, or medication label guidance.

¶ Two Interaction Types

¶ 1) Pharmacokinetic (levels change)

One compound changes how another is absorbed/metabolized/cleared (e.g., via CYP enzymes or transporters). This can raise toxicity risk or reduce effectiveness.

¶ 2) Pharmacodynamic (effects add up)

Two compounds push the same physiological system in the same direction (e.g., both lower blood pressure), increasing side-effect risk even if blood levels don’t change.

¶ High-Risk Medication Categories (Use Extra Caution)

If you’re taking any of these, pause and consult a clinician/pharmacist before stacking:

• Anticoagulants/antiplatelets (bleeding risk)
• Blood pressure medications (hypotension, dizziness, syncope)
• Diabetes medications (hypoglycemia risk)
• SSRIs/SNRIs/MAOIs and other psychoactives (mood, sleep, serotonin risk patterns)
• Antiarrhythmics and QT‑sensitive meds (rhythm risk)
• Immunosuppressants and transplant meds (narrow therapeutic windows)

¶ “Don’t Self‑Experiment” Triggers

• Pregnancy/breastfeeding (many supplements lack safety data)
• Chronic kidney disease or significant liver disease
• History of severe allergic reactions
• Prior arrhythmias or unexplained syncope
• Any new red-flag symptom: Red Flags

¶ How to Use This With the Library

When you read a protocol/intervention page, look for:

• Contraindications and caution groups
• Interaction notes (drug/supplement)
• A stop rule (what symptoms/lab changes should end the experiment)

For evidence standards, see: Evidence Grading & Editorial Policy